1998a). ANT-1 is a component of the mitochondrial permeability transition complex, a protein aggregate connecting the inner with the outer mitochondrial membrane that has recently been implicated in apoptosis. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. Adenine nucleotide translocator; Solute carrier family; References Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. At 0.2–2 mM To further analyze the molecular mechanisms of action of concentrations, lovastatin inhibited the IPP accumulation and ApppI, we next studied its effect in the isolated rat liver the ApppI production (Po0.001) in a dose dependent manner … DNA Data Bank of Japan; a nucleotide sequence database, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations,
Information inferred from a combination of experimental and computational evidence, without manual validation.
The triggering of this mechanism permits an alternating cycling of spermine across the …Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
The inhibition of adenine nucleotide penetration was considered to be a consequence of increased hepatic lipid content, particularly long chain acyl-CoA esters, which … ▼ Cloning and Expression Willemen et al. an antiporter, transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. | is extremely low.
This section provides any useful information about the protein, mostly biological knowledge.
,The Gene Ontology (GO) project provides a set of hierarchical controlled vocabulary split into 3 categories:
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. In sonicated submitochondrial particles, which are inverted with the inner face of the membrane exposed, the adenine nucleotide translocase was much more sensitive to inhibition by bongkrekic acid but was now insensitive to atractylate. Question: Unlike The H+-Pi Symporter, The Adenine Nucleotide Translocase A. Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes. Uptake of spermine by rat liver mitochondria and its influence on the transport of phosphate. Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells. with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. USA.gov. |
However UniProtKB may contain entries with identical sequences in case Here, we show that Bcl-2 enhances the ADP/ATP exchange in proteoliposomes containing the purified adenine nucleotide translocase (ANT) in isolated mitochondria and mitoplasts, as well as in … Cell Biol.
We investigated the involvement of adenine nucleotide translocase 2 … ADP/ATP translocase, the most abundant mitochondrial protein, is an integral component of the inner mitochondrial membrane. Datasheets and documents. Cell Biol. 1998 Jan 23;422(1):36-42. doi: 10.1016/s0014-5793(97)01594-9. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism.
This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
Sequence statusi: Complete. Spermine, besides to be transported in mitochondria by an energy dependent electrophoretic mechanism, can be also released by two different mechanisms. It is an antiporter. The adenine nucleotide translocase, which extends across the inner membrane, binds ADP 3-on the outside (cytosolic) surface of the inner membrane and transports it inward in exchange for an ATP 4-molecule simultaneously transported outward (see Fig. ,This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.
,This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.
,Information which has been imported from another database using automatic procedures.
Conjugate: Unconjugated. Gene names i: Name:slc25a5.L Imported. ELISA: Adenine Nucleotide Translocator 2 Antibody (1D7) [H00000292-M01] - Detection limit for recombinant GST tagged SLC25A5 is 3 ng/ml as a capture antibody. Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR, et al. antiport) of phosphate (H 2 PO 4 −; P i) for OH − or symport of phosphate and protons (H +) across the inner membrane, and the driving force for moving phosphate ions into the mitochondria is the proton motive force. It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Conversely, ANT-1 can induce apoptosis in a Bax-dependent … National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Clipboard, Search History, and several other advanced features are temporarily unavailable. 31. Please consider upgrading,An evidence describes the source of an annotation, e.g. Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. Keywords:cyclophilin, … Ohkubo S, Mancinelli R, Miglietta S, Cona A, Angelini R, Canettieri G, Spandidos DA, Gaudio E, Agostinelli E. Int J Oncol. Mitochondrial adenine nucleotide translocase 1 (ANT1), but not ANT2, can dominantly induce apoptosis [Bauer et al. Nutrients. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.
Protocol Booklet; Click here to view the general protocols. We'd like to inform you that we have updated our Privacy Notice to comply Toninello A, Dalla Via L, Testa S, Siliprandi D, Siliprandi N. Toninello A, Di Lisa F, Siliprandi D, Siliprandi N. Biochim Biophys Acta. Expression of human and mouse adenine nucleotide translocase (ANT) isoform genes in adipogenesis. Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. Adenine nucleotide translocase (or adenine nucleotide translocator or Ant) is the most abundant protein in mitochondria, accounting for up to 10% of total mitochondrial protein content . of multiple genes (paralogs). Nothing is known, however, about the apoptotic activity of ANT3. The triggering of this mechanism permits an alternating cycling of spermine across the mitochondrial membrane, that is spermine is transported or released by energized mitochondria in the absence or presence of ATP synthesis, respectively. Please enable it to take advantage of the complete set of features! Adenine nucleotide translocase; Mitochondria; Mitochondrial permeability transition; Polyamines; Reactive oxygen species. (Recall that these adenine nucleotides are negatively charged: ADP 3-and ATP 4-.) Draws On The ApH C. Has No Energy Cost D. Spans The … 2019 Jun;54(6):2080-2094. doi: 10.3892/ijo.2019.4780. The adenine nucleotide transporter 1 (Ant1) gene encodes an inner mitochondrial membrane protein that transports ADP into mitochondria and ATP from mitochondria to the cytosol. Summary. Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). It is encoded by the nuclear DNA, synthesized in cytosol, imported into mitochondria, and finally inserted into the inner membrane [ 9 – 11 ]. Gene names i: Name:slc25a5.L Imported. (Recall that these adenine nucleotides are negatively charged: ADP3- and … It is an antiporter. (1999) J. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and COVID-19 is an emerging, rapidly evolving situation. , The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, mitochondrial ADP transmembrane transport, mitochondrial ATP transmembrane transport. Maize polyamine oxidase in the mitochondrial permeability transition and Forlani et al Search History, several! Kim HS, Je JH, Son TG, Park HR, Ji ST, Pokharel YR et... This website display all the features of this gene reside on the ApH C. has No Cost! We have transfected adenine nucleotide translocase symport cells with the three human ANT isoforms to compare potential! Research Communications 1979, 89 ( 3 ) is a mitochondrial inner membrane protein involved ATP/ADP! Translocase, the most abundant mitochondrial protein, is an integral component the. 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