1. When Caroline Mary Luard was found murdered in the British town of Sea Chart in 1908, everyone suspected her husband. The real person responsible for this crime died long ago, going to his (or, based on recent speculation, her) grave knowing he got away with some of the most vicious, twisted murders in history. The mysteries on this list are some of the most brutal slayings in history and have yet to be solved. No list of unsolved murders would be complete without mention of Jack the Ripper — perhaps the single most infamous unsolved murder case in history to date. In 2008, Clint Eastwood’s film Changeling re-awakened interest in one of the most bizarre and tragic crime stories of the 1920s. Photo Credit: Crime Vault / YouTube; 4. California Natalie Wood and Robert Wagner at the 1960 Academy Awards . This is perhaps one of the most known unsolved murders in American history. This case from 1947 remains one of Hollywood's most intriguing unsolved murders, and its most gruesome. What are the most famous unsolved murder cases? RELATED: 10 Best Movies Based On Real Life Mysteries & Unsolved Crimes. O.J. The murders of Nicole Brown Simpson and Ron Goldman. was the defendant in the murder trial, but he … His alibi was perfect, but people made him a pariah, and he finally threw himself in front of a train.The only other suspect was a fraudster named John Dickman, and the main case against him was that he had the ridiculous name of "John Dickman." ... unsolved crime … A more recent unsolved mystery originating in Los Angeles is who murdered Nicole Brown Simpson and Ron Goldman.In June 1994, the 34-year-old ex-wife of American football star, O.J. One of the most notorious unsolved crime sprees in history goes to Jack the Ripper. 4. With stories of unsolved murders and disappearances and ghosts, the show helped solve a number of cold cases. We begin with the murder … In others, police didn't have any suspects or couldn't identify the victim. Jack the Ripper When the talk about the most mysterious murders of all time arises, Jack the Ripper … The Chilling, Unsolved Dardeen Family Murders. This list has them all. This was later ignored and a murder investigation went underway, but no one was ever found accountable. Some of those cases, however, made an impression on viewers and stayed with them long after the credits rolled. Read More About Jack the Ripper. Here are 10 famous unsolved murders of all time, where neither investigations nor evidences have met conclusions to determine the perpetrator. Photo Credit: Verging On / YouTube; 5. Fifty years on from the 300 Million Yen Robbery, the most famous bank heist in Japanese history, TW looks back at some high-profile cases that remain a mystery today. A Killer Calls: The Unsolved Murder of Dorothy Jane Scott. Interestingly, four witnesses were killed before they could testify. The identity of the killer who terrified East London in 1888 remains a mystery to this day. In some of these cases, people were charged only to be acquitted from a lack of evidence. Cruelly Slain: The Brutal Austin Yogurt Shop Murders of 1991 Remain Unsolved Decades Later. Jack the Ripper. A 22-year-old actress named Elizabeth Short was found murdered in a vacant lot in Los Angeles, her body sliced in half and three-inch gashes cut into each corner of her mouth, giving her a creepy, clown-esque smile. T hey are crimes that shocked the nation and bamboozled the police. Ripper is known for his activity in the impoverished areas of the Whitechapel district in London in 1888. Simpson, and 26-year-old Goldman were found stabbed to death outside of Nicole’s home. Dive into some of the most heinous unsolved mysteries that have baffled authorities for decades. No one has ever been held accountable for the murders. The Seal Chart Murder. 17: The Phantom Killer. 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