Zerbo, O., Ray, G.T., Fireman, B. et al. Annually, approximately 40,000 births occur at KPNC facilities. Statistical codes are not publicly available but are available from the corresponding author. Omicron data in UK is 'enormously worrying,' immunologist says "In the last two weeks, no fewer than 80% of admissions were below the age of 50 years. South Africa omicron crisis: Cases, hospitalizations and - CNBC Nature. As a result, the number of total hospitalizations exceeds the sum of unvaccinated adults, adults who received a primary series without a booster or additional dose, and adults who received a primary series with a booster or additional dose. Ann Intern Med 2021;174:140919. All rights Reserved. This preceded and had no relation to COVID-19, and GD had no role in and received no funding from the project. These findings are consistent with the diminishing of pregnancy-derived antibodies in infants over time22. Mortal. Like influenza and Tdap vaccines15,16, data suggest that vaccination during pregnancy may protect infants who are not old enough to be vaccinated against COVID-19. We ran separate models on the time periods associated with the Delta (7/01/2021 to 12/20/2021) and Omicron variants (12/21/2021 to 5/31/2022). We take your privacy seriously. Sect. Gordon, N. & Lin, T. The Kaiser Permanente Northern California adult member health survey. Correspondence to The U.K. Health. This analysis describes weekly hospitalization rates during Delta- and Omicron-predominant periods. Hospitalizations rates increased among all adults irrespective of vaccination status (unvaccinated, primary series only, or primary series plus a booster or additional dose). CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. CDC. All information these cookies collect is aggregated and therefore anonymous. 40, e137e145 (2021). In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: 21,48), 14% (CI: 9,32) and 13% (CI: 3,26), respectively. Second, vaccination status is subject to misclassification; this might affect estimation of rates by vaccination status. Real-world data suggest lower COVID-19 vaccine effectiveness against Omicron variants11,12,13,14. This is a relevant consideration because vaccines can be less effective in persons with a weakened immune system. MB), Help with Other studies found similarly decreased proportions of severe outcomes among hospitalized patients with COVID-19 during this period (6).. Iowa does not provide data on vaccination status. The cohort analyses may be biased toward the null if some infected infants were misclassified as uninfected due to the absence of a SARS-CoV-2 test result in the medical record. The results were published yesterday in JAMA Network Open. SARS-CoV-2 infections can result in COVID-19associated hospitalizations, even among vaccinated persons. COVID Data Tracker Weekly Review | CDC Informed consent was waived because this was a data-only study with no direct contact with participants. All adults should stay up to date (1) with COVID-19 vaccination to reduce their risk for COVID-19associated hospitalization. Razzaghi, H. et al. https://downloads.aap.org/AAP/PDF/AAP%20and%20CHA%20-%20Children%20and%20COVID-19%20State%20Data%20Report%209.29.22%20FINAL.pdf?_ga=2.255000394.335550773.1665001859-370326403.1636740765 (2022). Stay up to date with what you want to know. Sarah J. NMF, MC, GD, DDA, AMP, and ST supervised the work. Omicron Is Not More Severe for Children, Despite Rising Hospitalizations More children are being treated for Covid, but a combination of factors, including low vaccination rates, most. Omicron vaccine effectiveness estimates for 7 to 59 days, 60 to 119 days, and 240 days or more after the second dose are not presented owing to imprecision in the estimates and wide 95% CIs (ie, 100 percentage points). Our analysis . JAMA Intern. Rep. 71, 2630 (2022). Children currently account for about 18.5% of reported COVID-19 cases in the United States1. Clinical information was abstracted for 5,681 adults with COVID-19associated hospitalization during July 1, 2021January 31, 2022 (Table). Vaccine 40, 656665 (2022). The study had limitations worth noting. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Risk factors for severe COVID-19 in children. Garg S, Patel K, Pham H, et al. JAMA 327, 10871089 (2022). Furthermore, it was reassuring that both the cohort and the secondary TND yielded vaccine effectiveness estimates in the same direction. Stay up to date with your COVID-19 vaccines. Racial and ethnic disparities in rates of COVID-19associated hospitalization, intensive care unit admission, and in-hospital death in the United States from March 2020 to February 2021. Adults with a positive result whose SARS-CoV-2 test date was 14 days after the first dose of a 2-dose series but <14 days after receipt of the second dose were considered partially vaccinated. The company also said full results of its 2,250-person study confirmed the pill's promising early results against the virus: The drug reduced combined hospitalizations and deaths by about 89. Our primary cohort analysis used calendar days as the underlying scale to ensure that we compared infants of vaccinated and unvaccinated mothers on the same calendar days because vaccination status during pregnancy and risk of SARS-CoV-2 infection varied over the study period. In the meantime, to ensure continued support, we are displaying the site without styles These trends could result in epidemic phase bias if infection severity is correlated with time from infection to test. Immunogenicity and Reactogenicity of the Beta-variant Recombinant Variances were estimated using Taylor series linearization method. N. Engl. N. Engl. Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV Suggested citation for this article: Taylor CA, Whitaker M, Anglin O, et al. 20, 15225 (2016). 182, 825831 (2022). Google Scholar. Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19COVID-NET, 14 States, March 1-July 25, 2020. Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of
Accessed March 10, 2022. the date of publication. Method: This case-control study aims to determine the hospitalization risk associated with the inactivated BBIBP-CorV (Sinopharm) and mRNA BNT162b2 (Pfizer . During the Omicron-predominant period, weekly COVID-19associated hospitalization rates (hospitalizations per 100,000 adults) peaked at 38.4, compared with 15.5 during Delta predominance. Zerbo, O. et al. During Omicron predominance, children aged <6 months accounted for 44% of hospitalizations among children ages 04 years3. If SARS-CoV-2 test date was missing, hospitalization admission date was used. J. Obstet. Wkly. In conclusion, in this population-based cohort study, we found that infants born to mothers who received at least two doses of an mRNA COVID-19 vaccine during pregnancy were at lower risk of testing positive for SARS-CoV-2 and were at lower risk of hospitalization during the first 6 months of life compared with infants whose mothers were unvaccinated during pregnancy. Receipt of one dose especially during the third trimester was also associated with a reduced risk of infants testing positive for SARS-CoV-2 during the first 6 months of life during the Delta dominant period. Vaccine 35, 58505857 (2017). These results suggest that in addition to providing protection against testing positive, vaccination during pregnancy also provides protection against hospitalization (severe disease) in infants during their first 6 months of life as previously reported recently18,19. Foppa, I. M., Haber, M., Ferdinands, J. M. & Shay, D. K. The case test-negative design for studies of the effectiveness of influenza vaccine. Rep. 7, 255263 (2022). There was no link between risk of COVID-19 death and race, except for Indian patients, who were at slightly higher risk than their White peers. Rates cannot be stratified by pregnancy status because the underlying population of pregnant women in the catchment area is unknown. Age was the most important risk factor for COVID-19 death (eg, HR, 31.3 for an 80-year-old vs a 50-year-old). Evaluation of the relative virulence of novel SARS-CoV-2 variants: a retrospective cohort study in Ontario, Canada. Users are referred to the electronic PDF version (https://www.cdc.gov/mmwr)
The stats are for COVID-associated hospitalizations, which may include people for whom COVID-19 was not the primary reason for admission. The TND, a case-control study, has been commonly used in studies of the effectiveness of influenza vaccines and more recently COVID-19 vaccines. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Vaccinations were limited only to those received during pregnancy. RESP-NET: COVID-19 Associated Hospitalization Rates among Adults Ages 65 Years and Older CDC's Respiratory Virus Hospitalization Surveillance Network (RESP-NET) shows that overall weekly rates of COVID-19-associated hospitalizations have declined for all age groups from a peak in December 2022. No other exclusion criteria were applied. Starting the week ending December 4, 2021, Maryland data are not included in calculations but are included in previous weeks. COVID-19associated signs and symptoms included respiratory symptoms (congestion or runny nose, cough, hemoptysis or bloody sputum, shortness of breath or respiratory distress, sore throat, upper respiratory infection, influenza-like illness, and wheezing) and non-respiratory symptoms (abdominal pain, altered mental status or confusion, anosmia or decreased smell, chest pain, conjunctivitis, diarrhea, dysgeusia or decreased taste, fatigue, fever or chills, headache, muscle aches or myalgias, nausea or vomiting, rash, and seizures). In this primary design, all eligible infants meeting inclusion criteria were included without sampling which improved power and minimized bias related to selection. This correction ensures that there is always a reasonable denominator for the unvaccinated population that would prevent hospitalization rates from growing unrealistically large because of potential overestimates of vaccination coverage. B., Lewis. J. Med. During the Omicron-predominant period, peak hospitalization rates among non-Hispanic Black (Black) adults were nearly four times the rate of non-Hispanic White (White) adults and was the highest rate observed among any racial and ethnic group during the pandemic. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Three recent epidemiological studies found that vaccination during pregnancy was associated with a reduced risk of SARS-CoV-2 infection in infants during their first 4 months of life and a reduced risk of hospitalization during the first 5 months of life17,18,19. Published by Elsevier Ltd. BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. During the Delta dominant period, the crude incidences of testing positive for SARS-CoV-2 during the first 2, 4, and 6 months of life were lower among infants whose mothers received at least two doses of mRNA COVID-19 vaccines during pregnancy (0.75, 1.43, and 1.56 infants per 100 person-years [PY], respectively) than those whose mothers were not vaccinated during pregnancy (5.47, 5.10, and 4.78 infants per 100 PYs, respectively).